DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SCF_FBW7_1

Location: 446:453

E3 ligase: FBXW7

DEGRON score: 0.5187

ASA_SCORE: 62.125

COIL: 0.593

CONS_SCORE: 0.4637

DSS_SCORE: 0.6965

HELIX: 0.0395

FCONS_SCORE: 0.8001

RIG_SCORE: 0.5888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R442W	DO227988	COCA	ICGC	PWGTPGAS	DEG_SCF_FBW7_1	0.2222
p.S436F	DO37659	SKCM	ICGC	PWGTPGAS	DEG_SCF_FBW7_1	0.0556
p.S455G	DO229264	THCA	ICGC	PWGTPGAS	DEG_SCF_FBW7_1	0.2778
p.S441L	SIDM00007	Other Solid Cancers	GDSC	PWGTPGAS	DEG_SCF_FBW7_1	0.1944
p.S441L	ACH-001550	Skin Cancer	CCLE	PWGTPGAS	DEG_SCF_FBW7_1	0.1944
p.P439R	ACH-000341	Neuroblastoma	CCLE	PWGTPGAS	DEG_SCF_FBW7_1	0.1389
p.Q438R	ACH-000883	Brain Cancer	CCLE	PWGTPGAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SCF_FBW7_1	446:453	PWGTPGAS	FBXW7	0.5187	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons