DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SCF_TRCP1_1

Location: 2476:2481

E3 ligase: BTRC

DEGRON score: 0.9406

ASA_SCORE: 67.7

COIL: 0.8093

CONS_SCORE: 0.5824

DSS_SCORE: 0.6733

HELIX: 0.0905

FCONS_SCORE: 0.8313

RIG_SCORE: 0.498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2470C	DO44096	COAD	ICGC	DSGGAS	DEG_SCF_TRCP1_1	0.1667
p.A2480V	DO228338	MALY	ICGC	DSGGAS	DEG_SCF_TRCP1_1	0.5825
p.R2470S	ACH-001484	Leukemia	CCLE	DSGGAS	DEG_SCF_TRCP1_1	0.1667
p.R2470S	ACH-001485	Leukemia	CCLE	DSGGAS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SCF_TRCP1_1	2476:2481	DSGGAS	BTRC	0.9406	More...
Q6AWC2	Protein WWC2	DEG_SCF_TRCP1_1	609:614	DSGGAS	BTRC	0.9733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons