DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DGGGVVYSGTP
Uniprot ID:
Q8NDF8
Source protein:
Terminal nucleotidyltransferase 4B
Source gene:
TENT4B
Class:
CBL_PTK
Location:
97:107
E3 ligase:
CBL
DEGRON score:
0.9698
ASA_SCORE:
55.5273
COIL:
0.8375
CONS_SCORE:
0.3028
DSS_SCORE:
0.453
HELIX:
0.0231
FCONS_SCORE:
0.989
RIG_SCORE:
0.6877
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P90S
SIDM00250
Esophageal Squamous Cell Carcinoma
GDSC
DGGGVVYSGTP
CBL_PTK
0.1389
p.N99H
NB13
autonomic_ganglia
COSMIC
DGGGVVYSGTP
CBL_PTK
0.7423
p.G110R
STS-0421
soft_tissue
COSMIC
DGGGVVYSGTP
CBL_PTK
0.25
p.A103V
SNU-C5
large_intestine
COSMIC
DGGGVVYSGTP
CBL_PTK
0.6936
p.A103V
CW-2
large_intestine
COSMIC
DGGGVVYSGTP
CBL_PTK
0.6936
p.A103V
KYAE-1
oesophagus
COSMIC
DGGGVVYSGTP
CBL_PTK
0.6936
p.A103V
NCCIT
testis
COSMIC
DGGGVVYSGTP
CBL_PTK
0.6936
p.G104V
HCT-15
large_intestine
COSMIC
DGGGVVYSGTP
CBL_PTK
0.7532
p.R107Q
YT
haematopoietic_and_lymphoid_tissue
COSMIC
DGGGVVYSGTP
CBL_PTK
0.7329
Drug responses associated with TENT4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGGGVVYSGTP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDF8
Terminal nucleotidyltransferase 4B
CBL_PTK
97:107
DGGGVVYSGTP
CBL
0.9698
More...
