DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSDATPCK
Uniprot ID:
Q8NDF8
Source protein:
Terminal nucleotidyltransferase 4B
Source gene:
TENT4B
Class:
DEG_SCF_SKP2-CKS1_1
Location:
460:467
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9792
ASA_SCORE:
91.4375
COIL:
0.9346
CONS_SCORE:
0.198
DSS_SCORE:
0.5655
HELIX:
0.0422
FCONS_SCORE:
0.9397
RIG_SCORE:
0.6657
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V474A
SIDM01618
B-Lymphoblastic Leukemia
GDSC
DSDATPCK
DEG_SCF_SKP2-CKS1_1
0.1389
p.S465P
CAL-62
thyroid
COSMIC
DSDATPCK
DEG_SCF_SKP2-CKS1_1
0.6752
Drug responses associated with TENT4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSDATPCK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDF8
Terminal nucleotidyltransferase 4B
DEG_SCF_SKP2-CKS1_1
460:467
DSDATPCK
SKP2,CSK1
0.9792
More...