DegronMD

Uniprot ID: O60732

Source protein: Melanoma-associated antigen C1

Source gene: MAGEC1

Class: DEG_SPOP_SBC_1

Location: 411:415

E3 ligase: SPOP

DEGRON score: 0.9969

ASA_SCORE: 86.46

COIL: 0.9592

CONS_SCORE: 0.4048

DSS_SCORE: 0.3786

HELIX: 0.0226

FCONS_SCORE: 1

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F416V	TCGA-2W-A8YY	CESC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.3056
p.F416V	DO223732	CESC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.3056
p.Q409H	TCGA-44-5644	LUAD	TCGA	PMTSS	DEG_SPOP_SBC_1	0.2778
p.Q409H	DO25153	LUAD	ICGC	PMTSS	DEG_SPOP_SBC_1	0.2778
p.E401D	TCGA-55-8089	LUAD	TCGA	PMTSS	DEG_SPOP_SBC_1	0.0556
p.E401D	TCGA-56-7730	LUSC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.0556
p.E401D	DO23690	LUAD	ICGC	PMTSS	DEG_SPOP_SBC_1	0.0556
p.E401D	DO26617	LUSC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.0556
p.L421F	TCGA-56-7731	LUSC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1667
p.L421F	TCGA-FU-A23L	CESC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1667
p.L421F	DO6278	CESC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1667
p.L421F	DO45527	LUSC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1667
p.P411T	TCGA-AA-A010	COAD	TCGA	PMTSS	DEG_SPOP_SBC_1	0.7031
p.P404S	TCGA-D9-A1JW	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P404S	TCGA-EE-A2GM	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P404S	TCGA-FW-A3R5	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P404S	DO220903	MELA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P404S	DO37555	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P404S	DO37786	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P404S	DO37406	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1389
p.P411S	TCGA-EE-A2GH	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	0.6752
p.P411S	DO37643	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	0.6752
p.I423L	TCGA-P3-A6T7	HNSC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1111
p.I423L	TCGA-YL-A8SO	PRAD	TCGA	PMTSS	DEG_SPOP_SBC_1	0.1111
p.I423L	DO49033	HNSC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1111
p.I423L	DO51436	PRAD	ICGC	PMTSS	DEG_SPOP_SBC_1	0.1111
p.P411H	DO222874	COCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.7694
p.P407T	DO222441	ESCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.2222
p.G402D	DO229453	SKCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.0833
p.P404A	SIDM00967	Ovarian Carcinoma	GDSC	PMTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	198:202	PMTSS	SPOP	0.9993	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	411:415	PMTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMTSS

Degron related mutations and impact score

Drug responses associated with MAGEC1 mutations

All proteins holding degron of PMTSS