DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_APCC_KENBOX_2

Location: 1286:1290

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7173

ASA_SCORE: 95.94

COIL: 0.7158

CONS_SCORE: 0.3482

DSS_SCORE: 0.5373

HELIX: 0.219

FCONS_SCORE: 1.0428

RIG_SCORE: 0.7239

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1289S	TCGA-AA-3519	COAD	TCGA	GKENF	DEG_APCC_KENBOX_2	0.7069
p.N1289S	DO7914	COAD	ICGC	GKENF	DEG_APCC_KENBOX_2	0.7069
p.E1288K	TCGA-AX-A05Z	UCEC	TCGA	GKENF	DEG_APCC_KENBOX_2	0.7022
p.E1288K	DO40884	UCEC	ICGC	GKENF	DEG_APCC_KENBOX_2	0.7022
p.E1296K	TCGA-DK-AA76	BLCA	TCGA	GKENF	DEG_APCC_KENBOX_2	0.1667
p.E1296K	DO219013	BLCA	ICGC	GKENF	DEG_APCC_KENBOX_2	0.1667
p.E1277Q	SIDM02040	Esophageal Carcinoma	GDSC	GKENF	DEG_APCC_KENBOX_2	0.0833

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	DEG_APCC_KENBOX_2	485:489	GKENF	APC,CDC20,FZR1	0.9658	More...
P16519	Neuroendocrine convertase 2	DEG_APCC_KENBOX_2	496:500	GKENF	APC,CDC20,FZR1	0.5817	More...
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_APCC_KENBOX_2	1286:1290	GKENF	APC,CDC20,FZR1	0.7173	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons