DegronMD

Uniprot ID: Q13557

Source protein: Calcium/calmodulin-dependent protein kinase type II subunit delta

Source gene: CAMK2D

Class: DEG_APCC_KENBOX_2

Location: 485:489

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9658

ASA_SCORE: 87.56

COIL: 0.8004

CONS_SCORE: 0.1584

DSS_SCORE: 0.522

HELIX: 0.0548

FCONS_SCORE: 0.882

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I499T	TCGA-AX-A05Z	UCEC	TCGA	GKENF	DEG_APCC_KENBOX_2	0.0556
p.P480S	TCGA-ER-A193	SKCM	TCGA	GKENF	DEG_APCC_KENBOX_2	0.1944
p.W489C	DO10443	COAD	ICGC	GKENF	DEG_APCC_KENBOX_2	0.7
p.R492Q	DO222741	COCA	ICGC	GKENF	DEG_APCC_KENBOX_2	0.25
p.H490Q	DO229034	LICA	ICGC	GKENF	DEG_APCC_KENBOX_2	0.75
p.D493N	DO27580	LUSC	ICGC	GKENF	DEG_APCC_KENBOX_2	0.2222
p.M477I	DO32347	OV	ICGC	GKENF	DEG_APCC_KENBOX_2	0.1111
p.R487C	DO223286	UCEC	ICGC	GKENF	DEG_APCC_KENBOX_2	0.8301
p.G482W	SN12C	kidney	COSMIC	GKENF	DEG_APCC_KENBOX_2	0.25
p.G485W	SN12C	kidney	COSMIC	GKENF	DEG_APCC_KENBOX_2	0.6714

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_APCC_KENBOX_2	1286:1290	GKENF	APC,CDC20,FZR1	0.7173	More...
P16519	Neuroendocrine convertase 2	DEG_APCC_KENBOX_2	496:500	GKENF	APC,CDC20,FZR1	0.5817	More...
Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	DEG_APCC_KENBOX_2	485:489	GKENF	APC,CDC20,FZR1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons