DegronMD - P16519(PCSK2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R502C	TCGA-A6-6654	COAD	TCGA	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.2778
p.R502C	TCGA-BR-4256	STAD	TCGA	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.2778
p.R502C	DO9498	COAD	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.2778
p.R502C	DO38743	STAD	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.2778
p.F500S	TCGA-BS-A0UF	UCEC	TCGA	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation altering degron motif	0.6871
p.F500S	DO41488	UCEC	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation altering degron motif	0.6871
p.E495A	TCGA-D8-A1XK	BRCA	TCGA	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.3056
p.E495A	DO4749	BRCA	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.3056
p.G496R	TCGA-FW-A3R5	SKCM	TCGA	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation altering degron motif	0.6457
p.G496R	DO37406	SKCM	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation altering degron motif	0.6457
p.A509V	TCGA-WW-A8ZI	PRAD	TCGA	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.0833
p.A509V	DO49865	PRAD	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.0833
p.V486A	DO18392	KIRC	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.0556
p.R502L	DO229025	LICA	ICGC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.2778
p.G496E	SIDM00258	Neuroblastoma	GDSC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation altering degron motif	0.6087
p.G496E	NB12	autonomic ganglia	COSMIC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation altering degron motif	0.6087
p.M506I	NCI-H211	lung	COSMIC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.1667
p.M490I	NCI-H211	lung	COSMIC	GKENF	DEG_APCC_KENBOX_2	496:500	Mutation rewiring degron network	0.1667

Kaplan plot for PCSK2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCSK2

UniProt ID: P16519

Entrez ID: 5126

Protein name: Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PCSK2 in