DegronMD

Uniprot ID: P16519

Source protein: Neuroendocrine convertase 2

Source gene: PCSK2

Class: DEG_APCC_KENBOX_2

Location: 496:500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5817

ASA_SCORE: 87.48

COIL: 0.7858

CONS_SCORE: 0.2962

DSS_SCORE: 0.1883

HELIX: 0.0264

FCONS_SCORE: 0.77

RIG_SCORE: 0.8313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R502C	TCGA-A6-6654	COAD	TCGA	GKENF	DEG_APCC_KENBOX_2	0.2778
p.R502C	TCGA-BR-4256	STAD	TCGA	GKENF	DEG_APCC_KENBOX_2	0.2778
p.R502C	DO9498	COAD	ICGC	GKENF	DEG_APCC_KENBOX_2	0.2778
p.R502C	DO38743	STAD	ICGC	GKENF	DEG_APCC_KENBOX_2	0.2778
p.F500S	TCGA-BS-A0UF	UCEC	TCGA	GKENF	DEG_APCC_KENBOX_2	0.6871
p.F500S	DO41488	UCEC	ICGC	GKENF	DEG_APCC_KENBOX_2	0.6871
p.E495A	TCGA-D8-A1XK	BRCA	TCGA	GKENF	DEG_APCC_KENBOX_2	0.3056
p.E495A	DO4749	BRCA	ICGC	GKENF	DEG_APCC_KENBOX_2	0.3056
p.G496R	TCGA-FW-A3R5	SKCM	TCGA	GKENF	DEG_APCC_KENBOX_2	0.6457
p.G496R	DO37406	SKCM	ICGC	GKENF	DEG_APCC_KENBOX_2	0.6457
p.A509V	TCGA-WW-A8ZI	PRAD	TCGA	GKENF	DEG_APCC_KENBOX_2	0.0833
p.A509V	DO49865	PRAD	ICGC	GKENF	DEG_APCC_KENBOX_2	0.0833
p.V486A	DO18392	KIRC	ICGC	GKENF	DEG_APCC_KENBOX_2	0.0556
p.R502L	DO229025	LICA	ICGC	GKENF	DEG_APCC_KENBOX_2	0.2778
p.G496E	SIDM00258	Neuroblastoma	GDSC	GKENF	DEG_APCC_KENBOX_2	0.6087
p.G496E	NB12	autonomic_ganglia	COSMIC	GKENF	DEG_APCC_KENBOX_2	0.6087
p.M506I	NCI-H211	lung	COSMIC	GKENF	DEG_APCC_KENBOX_2	0.1667
p.M490I	NCI-H211	lung	COSMIC	GKENF	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_APCC_KENBOX_2	1286:1290	GKENF	APC,CDC20,FZR1	0.7173	More...
P16519	Neuroendocrine convertase 2	DEG_APCC_KENBOX_2	496:500	GKENF	APC,CDC20,FZR1	0.5817	More...
Q13557	Calcium/calmodulin-dependent protein kinase type II subunit delta	DEG_APCC_KENBOX_2	485:489	GKENF	APC,CDC20,FZR1	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons