DegronMD

Uniprot ID: P48764

Source protein: Sodium/hydrogen exchanger 3

Source gene: SLC9A3

Class: DEG_APCC_DBOX_1

Location: 552:560

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8448

ASA_SCORE: 97.4556

COIL: 0.6751

CONS_SCORE: 0.3452

DSS_SCORE: 0.2821

HELIX: 0.278

FCONS_SCORE: 1.0303

RIG_SCORE: 0.7609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R552H	TCGA-AA-3864	COAD	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.7133
p.S545G	TCGA-AJ-A3BH	UCEC	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.5833
p.R553C	TCGA-DA-A95Z	SKCM	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.8301
p.A543T	TCGA-DU-6392	LGG	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.0833
p.V568I	TCGA-EE-A2MR	SKCM	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.1111
p.S545R	TCGA-FI-A2F4	UCEC	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.5833
p.S561Y	TCGA-FV-A2QR	LIHC	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.3056
p.D542N	TCGA-R5-A7O7	STAD	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.0556
p.R553H	TCGA-VQ-A8P2	STAD	TCGA	RRGSLAFIR	DEG_APCC_DBOX_1	0.8244
p.R543H	DO8490	COAD	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.0833
p.V561M	DO8224	COAD	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.3056
p.F563L	DO228974	LICA	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.6944
p.N560K	DO229045	LICA	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.6918
p.S552Y	DO22837	LIHC	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.712
p.V559I	DO37819	SKCM	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.7076
p.R544C	DO219481	SKCM	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.1111
p.R544H	DO51761	STAD	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.1111
p.R566Q	DO41572	UCEC	ICGC	RRGSLAFIR	DEG_APCC_DBOX_1	0.1667
p.D542Y	SIDM00789	Colorectal Carcinoma	GDSC	RRGSLAFIR	DEG_APCC_DBOX_1	0.0556
p.D542Y	ACH-000997	Colon/Colorectal Cancer	CCLE	RRGSLAFIR	DEG_APCC_DBOX_1	0.0556
p.D542Y	HCT-15	large_intestine	COSMIC	RRGSLAFIR	DEG_APCC_DBOX_1	0.0556
p.S561F	SIDM01735	Biliary Tract Carcinoma	GDSC	RRGSLAFIR	DEG_APCC_DBOX_1	0.3056
p.S561F	ACH-000808	Bile Duct Cancer	CCLE	RRGSLAFIR	DEG_APCC_DBOX_1	0.3056
p.T564K	IST-SL1	lung	COSMIC	RRGSLAFIR	DEG_APCC_DBOX_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48764	Sodium/hydrogen exchanger 3	DEG_APCC_DBOX_1	552:560	RRGSLAFIR	APC,CDC20,FZR1	0.8448	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons