DegronMD

Uniprot ID: P48764

Source protein: Sodium/hydrogen exchanger 3

Source gene: SLC9A3

Class: DEG_SCF_FBW7_1

Location: 570:577

E3 ligase: FBXW7

DEGRON score: 0.9901

ASA_SCORE: 87.775

COIL: 0.8803

CONS_SCORE: 0.3885

DSS_SCORE: 0.31

HELIX: 0.071

FCONS_SCORE: 1.3038

RIG_SCORE: 0.7865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V570M	TCGA-AA-3492	COAD	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	0.6097
p.R575Q	TCGA-AX-A2HC	UCEC	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	0.6218
p.V568I	TCGA-EE-A2MR	SKCM	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	0.2778
p.S561Y	TCGA-FV-A2QR	LIHC	TCGA	VDFTPRSS	DEG_SCF_FBW7_1	0.0833
p.V561M	DO8224	COAD	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.0833
p.E580Q	DO52079	HNSC	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.25
p.V585A	DO22237	LGG	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.1111
p.F563L	DO228974	LICA	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.5833
p.E580K	DO25847	LUAD	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.25
p.A584T	DO229253	THCA	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.1389
p.R566Q	DO41572	UCEC	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.2222
p.N581Y	DO41903	UCEC	ICGC	VDFTPRSS	DEG_SCF_FBW7_1	0.2222
p.T573K	SIDM00223	Small Cell Lung Carcinoma	GDSC	VDFTPRSS	DEG_SCF_FBW7_1	0.7306
p.T573K	ACH-002144	Lung Cancer	CCLE	VDFTPRSS	DEG_SCF_FBW7_1	0.7306
p.T573K	IST-SL1	lung	COSMIC	VDFTPRSS	DEG_SCF_FBW7_1	0.7306
p.S561F	SIDM01735	Biliary Tract Carcinoma	GDSC	VDFTPRSS	DEG_SCF_FBW7_1	0.0833
p.S561F	ACH-000808	Bile Duct Cancer	CCLE	VDFTPRSS	DEG_SCF_FBW7_1	0.0833
p.T564K	IST-SL1	lung	COSMIC	VDFTPRSS	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48764	Sodium/hydrogen exchanger 3	DEG_SCF_FBW7_1	570:577	VDFTPRSS	FBXW7	0.9901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons