DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 1844:1848

E3 ligase: SPOP

DEGRON score: 0.7668

ASA_SCORE: 91.68

COIL: 0.6816

CONS_SCORE: 0.541

DSS_SCORE: 0.5163

HELIX: 0.0158

FCONS_SCORE: 1.2025

RIG_SCORE: 0.7305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1856L	TCGA-50-5930	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1111
p.V1856L	DO25189	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.T1848S	TCGA-64-1679	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.6005
p.T1848S	DO26200	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.6005
p.D1843N	TCGA-AG-4015	READ	TCGA	PETTT	DEG_SPOP_SBC_1	0.3056
p.D1843N	DO233765	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.D1843N	DO36459	READ	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.V1849G	TCGA-BS-A0UJ	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.3056
p.V1849G	DO42745	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.P1844S	TCGA-D3-A8GR	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.6752
p.P1844S	DO51247	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.6752
p.S1853L	DO220901	MELA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1944
p.V1856I	DO51507	PACA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.V1856I	SIDM00217	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.1111
p.V1856I	SNU-1040	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1111
p.L1854S	SIDM00602	Gastric Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.1667
p.L1854S	ACH-000919	Gastric Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.1667
p.L1854S	IM-95	stomach	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1667
p.T1847N	SIDM00359	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.7055
p.T1847N	ACH-000565	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.7055
p.T1847N	RCM-1	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.7055
p.G1847D	SK-UT-1	soft_tissue	COSMIC	PETTT	DEG_SPOP_SBC_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons