DegronMD

Uniprot ID: O94817

Source protein: Ubiquitin-like protein ATG12

Source gene: ATG12

Class: DEG_SPOP_SBC_1

Location: 27:31

E3 ligase: SPOP

DEGRON score: 0.8998

ASA_SCORE: 102

COIL: 0.9428

CONS_SCORE: 0.3257

DSS_SCORE: 0.8195

HELIX: 0.0276

FCONS_SCORE: 1.0168

RIG_SCORE: 0.6021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G21R	TCGA-CG-5716	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1667
p.G21R	DO38393	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1667
p.P32T	TCGA-DA-A1IB	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.3056
p.P32T	DO38033	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.A17S	TCGA-DD-AACM	LIHC	TCGA	PETTT	DEG_SPOP_SBC_1	0.0556
p.A17S	DO52209	LIHC	ICGC	PETTT	DEG_SPOP_SBC_1	0.0556
p.R19G	DO229005	COCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.R27I	DO30670	OV	ICGC	PETTT	DEG_SPOP_SBC_1	0.8102
p.A24T	DO41847	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons