DegronMD

Uniprot ID: Q9UHW9

Source protein: Solute carrier family 12 member 6

Source gene: SLC12A6

Class: DEG_SPOP_SBC_1

Location: 4:8

E3 ligase: SPOP

DEGRON score: 0.9865

ASA_SCORE: 102.46

COIL: 0.9518

CONS_SCORE: 0.0837

DSS_SCORE: 0.7885

HELIX: 0.0236

FCONS_SCORE: 0.5717

RIG_SCORE: 0.7081

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4Q	TCGA-D3-A2JP	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.7035
p.P4Q	DO47407	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.7035
p.F15L	TCGA-E5-A4TZ	BLCA	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.F15L	DO44055	BLCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.P4L	TCGA-EE-A180	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.7582
p.P4L	DO47537	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.7582
p.K9N	TCGA-EY-A1GI	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.3056
p.K9N	DO41211	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.R14Q	TCGA-F1-6874	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1667
p.R14Q	DO38201	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1667
p.A7V	DO219887	DLBC	ICGC	PETTT	DEG_SPOP_SBC_1	0.6936
p.A17E	DO229022	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.0833
p.A17E	DO229026	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.0833
p.P3H	DO229035	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.P12A	DO50974	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.2222
p.M4K	DO231545	LINC	ICGC	PETTT	DEG_SPOP_SBC_1	0.8062
p.G6R	DO45339	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.7568
p.G15V	DO229213	THCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.V9A	DO41331	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.M10L	SIDM02026	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons