DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11429:11433

E3 ligase: SPOP

DEGRON score: 0.8471

ASA_SCORE: 87.86

COIL: 0.7396

CONS_SCORE: 0

DSS_SCORE: 0.5058

HELIX: 0.0208

FCONS_SCORE: 0

RIG_SCORE: 0.7196

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11429S	TCGA-AP-A0LM	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.6752
p.P11429S	DO43306	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.6752
p.E11430D	TCGA-B5-A0JY	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.5647
p.E11430D	DO43041	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.5647
p.T11432I	TCGA-BG-A222	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.7078
p.T11432I	DO42977	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.7078
p.T11432R	TCGA-DX-A8BU	SARC	TCGA	PETTT	DEG_SPOP_SBC_1	0.7876
p.T11432R	TCGA-EE-A2M6	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.7876
p.T11432R	DO220065	SARC	ICGC	PETTT	DEG_SPOP_SBC_1	0.7876
p.T11432R	DO37976	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.7876
p.G11427S	TCGA-IH-A3EA	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.2778
p.G11427S	DO37667	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.2778
p.P11429Q	DO229018	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.7035
p.T11433N	DO229036	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.7055
p.P11420S	DO220902	MELA	ICGC	PETTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons