DegronMD

Uniprot ID: P07498

Source protein: Kappa-casein

Source gene: CSN3

Class: DEG_SPOP_SBC_1

Location: 170:174

E3 ligase: SPOP

DEGRON score: 0.991

ASA_SCORE: 87.46

COIL: 0.5576

CONS_SCORE: 0.8206

DSS_SCORE: 0.6003

HELIX: 0.0204

FCONS_SCORE: 1.2577

RIG_SCORE: 0.7382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T181M	TCGA-06-0195	GBM	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.T181M	TCGA-D1-A0ZO	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.T181M	DO222846	COCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.T181M	DO13468	GBM	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.T181M	DO41927	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.T173N	TCGA-39-5011	LUSC	TCGA	PETTT	DEG_SPOP_SBC_1	0.7055
p.T173N	DO27532	LUSC	ICGC	PETTT	DEG_SPOP_SBC_1	0.7055
p.P170H	TCGA-78-7161	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.7694
p.P170H	DO25975	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.7694
p.T181R	TCGA-83-5908	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.T181R	DO23572	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.A182S	TCGA-86-8674	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1111
p.A182S	DO25535	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.T172P	TCGA-E6-A1LX	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.7031
p.T172P	DO41020	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.7031
p.V177A	DO233871	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	0.25
p.T181S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.1389
p.T181S	ACH-000813	Lung Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons