DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 928:932

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 102.56

COIL: 0.9514

CONS_SCORE: 0.1583

DSS_SCORE: 0.7432

HELIX: 0.0146

FCONS_SCORE: 1

RIG_SCORE: 0.7089

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D923E	TCGA-AX-A05Z	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1944
p.D923E	DO40884	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1944
p.D923Y	TCGA-BS-A0UV	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1944
p.D923Y	DO42793	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1944
p.A933V	TCGA-DF-A2KU	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.3056
p.A933V	DO223286	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.E940Q	TCGA-DK-A6B6	BLCA	TCGA	PETTT	DEG_SPOP_SBC_1	0.1111
p.E940Q	DO48576	BLCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.K918N	TCGA-EO-A3B0	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1667
p.K918N	DO219773	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1667
p.D923N	TCGA-IB-7651	PAAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1944
p.D923N	DO46657	PAAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1944
p.A934V	TCGA-VQ-A8PB	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.2778
p.A934V	DO51766	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.2778
p.T932I	TCGA-VQ-A8PE	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.8189
p.T932I	DO51769	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.8189
p.A942G	TCGA-VQ-AA64	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.0556
p.A942G	DO222381	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.0556
p.K918R	DO233267	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1667
p.A934T	DO233882	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	0.2778
p.A934T	NCI-H1417	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	0.2778
p.T930A	SIDM00487	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.7139
p.T930A	ACH-000963	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.7139
p.T930A	CCK-81	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.7139
p.K936M	SIDM00220	Ovarian Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.3333
p.K936M	OC-314	ovary	COSMIC	PETTT	DEG_SPOP_SBC_1	0.3333
p.K936T	SIDM01588	Endometrial Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.3333
p.K936T	ACH-000993	Endometrial/Uterine Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.3333
p.S921C	HT-3	cervix	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1389
p.S919C	HT-3	cervix	COSMIC	PETTT	DEG_SPOP_SBC_1	0.0833
p.A923T	LS-411N	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PETTT