DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11177:11181

E3 ligase: SPOP

DEGRON score: 0.6393

ASA_SCORE: 90.52

COIL: 0.7206

CONS_SCORE: 0

DSS_SCORE: 0.5254

HELIX: 0.023

FCONS_SCORE: 0

RIG_SCORE: 0.7259

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V11184I	TCGA-2W-A8YY	CESC	TCGA	PETTT	DEG_SPOP_SBC_1	0.25
p.V11184I	DO223732	CESC	ICGC	PETTT	DEG_SPOP_SBC_1	0.25
p.E11178D	TCGA-AP-A1DV	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.5647
p.E11178D	DO8898	COAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.5647
p.E11178D	DO43186	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.5647
p.S11173Y	TCGA-CA-6718	COAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.2222
p.S11173Y	DO7801	COAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.2222
p.I11172V	TCGA-CC-A7IH	LIHC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1944
p.I11172V	DO52181	LIHC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1944
p.E11188D	TCGA-DF-A2KN	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.E11188D	DO223282	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.M11191I	TCGA-EE-A2GC	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.0556
p.M11191I	DO37839	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.0556
p.S11187F	TCGA-FS-A1ZW	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.1667
p.S11187F	DO37519	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.1667
p.S11173F	TCGA-GF-A6C9	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.2222
p.S11173F	DO51254	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.2222
p.S11174F	TCGA-WE-A8ZX	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.25
p.S11174F	DO51291	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.25
p.S11182L	TCGA-YD-A89C	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.3056
p.S11182L	DO219501	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.3056
p.E11188Q	DO223057	ESCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.T11179S	DO229047	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.6005
p.P11177T	DO229009	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.7031
p.T11169I	DO220899	MELA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.P11168L	SIDM00521	Small Cell Lung Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.0833
p.P11168L	ACH-000743	Lung Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.0833
p.P11168L	COR-L95	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	0.0833
p.T11180A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.7139
p.T11180A	SIDM00454	Rhabdomyosarcoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.7139
p.T11171I	SIDM00150	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.1667
p.T11171I	ACH-000969	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.1667
p.T11171I	KM12	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1667
p.D11175N	SIDM01640	Acute Myeloid Leukemia	GDSC	PETTT	DEG_SPOP_SBC_1	0.2778
p.D11175N	ACH-000602	Leukemia	CCLE	PETTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETTT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PETTT