DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: DEG_SPOP_SBC_1

Location: 602:606

E3 ligase: SPOP

DEGRON score: 0.8571

ASA_SCORE: 100.32

COIL: 0.922

CONS_SCORE: 0.377

DSS_SCORE: 0.8379

HELIX: 0.0216

FCONS_SCORE: 1.0243

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K614I	TCGA-06-5416	GBM	TCGA	PETTT	DEG_SPOP_SBC_1	0.2222
p.K614I	DO10880	GBM	ICGC	PETTT	DEG_SPOP_SBC_1	0.2222
p.M594I	TCGA-AA-3877	COAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1111
p.M594I	DO7855	COAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.M594I	DO229470	SKCA	ICGC	PETTT	DEG_SPOP_SBC_1	0.1111
p.E595Q	TCGA-BK-A0C9	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.E595Q	DO41253	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.E595K	TCGA-EE-A182	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.1389
p.E595K	DO37814	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.1389
p.G609W	TCGA-EE-A29L	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	0.25
p.G609W	DO37835	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	0.25
p.D615Y	SIDM00118	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.0833
p.D615Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.0833
p.D615Y	HCC2998	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons