DegronMD - P07498(CSN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T181M	TCGA-06-0195	GBM	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181M	TCGA-06-0195	GBM	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T181M	TCGA-D1-A0ZO	UCEC	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181M	TCGA-D1-A0ZO	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T181M	DO222846	COCA	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181M	DO222846	COCA	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T181M	DO13468	GBM	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181M	DO13468	GBM	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T181M	DO41927	UCEC	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181M	DO41927	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T173N	TCGA-39-5011	LUSC	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7055
p.T173N	TCGA-39-5011	LUSC	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7055
p.T173N	DO27532	LUSC	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7055
p.T173N	DO27532	LUSC	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7055
p.P170H	TCGA-78-7161	LUAD	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7694
p.P170H	TCGA-78-7161	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7694
p.P170H	DO25975	LUAD	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.7694
p.P170H	DO25975	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7694
p.T181R	TCGA-83-5908	LUAD	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181R	TCGA-83-5908	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T181R	DO23572	LUAD	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181R	DO23572	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.A182S	TCGA-86-8674	LUAD	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.0833
p.A182S	TCGA-86-8674	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.A182S	DO25535	LUAD	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.0833
p.A182S	DO25535	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.T172P	TCGA-E6-A1LX	UCEC	TCGA	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.5919
p.T172P	TCGA-E6-A1LX	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7031
p.T172P	DO41020	UCEC	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.5919
p.T172P	DO41020	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.7031
p.V177A	DO233871	GACA	ICGC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.2222
p.V177A	DO233871	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.25
p.T181S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T181S	ACH-000813	Lung Cancer	CCLE	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation rewiring degron network	0.1111
p.T181S	ACH-000813	Lung Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.T167M	ACH-000208	Brain Cancer	CCLE	ITSTPETT	DEG_SCF_FBW7_1	166:173	Mutation altering degron motif	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSN3

UniProt ID: P07498

Entrez ID: 1448

Protein name: Kappa-casein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSN3 in