DegronMD

Uniprot ID: P07498

Source protein: Kappa-casein

Source gene: CSN3

Class: DEG_SCF_FBW7_1

Location: 166:173

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 82.45

COIL: 0.6556

CONS_SCORE: 0.7936

DSS_SCORE: 0.5726

HELIX: 0.0251

FCONS_SCORE: 1.2551

RIG_SCORE: 0.7256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T181M	TCGA-06-0195	GBM	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T181M	TCGA-D1-A0ZO	UCEC	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T181M	DO222846	COCA	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T181M	DO13468	GBM	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T181M	DO41927	UCEC	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T173N	TCGA-39-5011	LUSC	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.7055
p.T173N	DO27532	LUSC	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.7055
p.P170H	TCGA-78-7161	LUAD	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.7694
p.P170H	DO25975	LUAD	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.7694
p.T181R	TCGA-83-5908	LUAD	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T181R	DO23572	LUAD	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.A182S	TCGA-86-8674	LUAD	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.0833
p.A182S	DO25535	LUAD	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.0833
p.T172P	TCGA-E6-A1LX	UCEC	TCGA	ITSTPETT	DEG_SCF_FBW7_1	0.5919
p.T172P	DO41020	UCEC	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.5919
p.V177A	DO233871	GACA	ICGC	ITSTPETT	DEG_SCF_FBW7_1	0.2222
p.T181S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T181S	ACH-000813	Lung Cancer	CCLE	ITSTPETT	DEG_SCF_FBW7_1	0.1111
p.T167M	ACH-000208	Brain Cancer	CCLE	ITSTPETT	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07498	Kappa-casein	DEG_SCF_FBW7_1	166:173	ITSTPETT	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons