DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PETTT
Uniprot ID:
Q63HN1
Source protein:
Putative protein FAM205B
Source gene:
FAM205BP
Class:
DEG_SPOP_SBC_1
Location:
292:296
E3 ligase:
SPOP
DEGRON score:
0.5845
ASA_SCORE:
80.22
COIL:
0.8544
CONS_SCORE:
0
DSS_SCORE:
0.6038
HELIX:
0.0436
FCONS_SCORE:
0
RIG_SCORE:
0.65
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM205BP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PETTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94817
Ubiquitin-like protein ATG12
DEG_SPOP_SBC_1
27:31
PETTT
SPOP
0.8998
More...
P07498
Kappa-casein
DEG_SPOP_SBC_1
170:174
PETTT
SPOP
0.991
More...
P13611
Versican core protein
DEG_SPOP_SBC_1
1844:1848
PETTT
SPOP
0.7668
More...
P57071
PR domain zinc finger protein 15
DEG_SPOP_SBC_1
1263:1267
PETTT
SPOP
0.74
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
984:988
PETTT
SPOP
0.91
More...
Q08379
Golgin subfamily A member 2
DEG_SPOP_SBC_1
56:60
PETTT
SPOP
0.8756
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11177:11181
PETTT
SPOP
0.6393
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
11429:11433
PETTT
SPOP
0.8471
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
928:932
PETTT
SPOP
0.9958
More...
Q9NYA3
Golgin subfamily A member 6A
DEG_SPOP_SBC_1
55:59
PETTT
SPOP
0.6277
More...
Q9UHW9
Solute carrier family 12 member 6
DEG_SPOP_SBC_1
4:8
PETTT
SPOP
0.9865
More...
Q8N9W4
Golgin subfamily A member 6-like protein 2
DEG_SPOP_SBC_1
58:62
PETTT
SPOP
0.9524
More...
A6NDN3
Golgin subfamily A member 6B
DEG_SPOP_SBC_1
55:59
PETTT
SPOP
0.9725
More...
Q9ULL0
Acrosomal protein KIAA1210
DEG_SPOP_SBC_1
602:606
PETTT
SPOP
0.8571
More...
Q63HN1
Putative protein FAM205B
DEG_SPOP_SBC_1
292:296
PETTT
SPOP
0.5845
More...
Q6ZU69
Protein FAM205A
DEG_SPOP_SBC_1
562:566
PETTT
SPOP
0.6816
More...