DegronMD - Q08379(GOLGA2)

FUNCTION: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401). {ECO:0000250|UniProtKB:Q62839, ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A693T	TCGA-19-5956	GBM	TCGA	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.6028
p.A693T	DO13863	GBM	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.6028
p.K48N	TCGA-50-5946	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.2222
p.K48N	TCGA-55-A4DF	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.2222
p.K48N	SIDM01588	Endometrial Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.2222
p.K48N	ACH-000993	Endometrial/Uterine Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.2222
p.K47R	TCGA-AA-3713	COAD	TCGA	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.1944
p.K47R	DO8400	COAD	ICGC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.1944
p.R703Q	TCGA-DF-A2KU	UCEC	TCGA	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.0556
p.R703Q	DO223286	UCEC	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.0556
p.T70I	TCGA-DF-A2KU	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0556
p.T70I	DO223286	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.0556
p.K46R	TCGA-F1-6874	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.1667
p.E57K	TCGA-XF-AAML	BLCA	TCGA	PETTT	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.591
p.L701V	DO224667	BRCA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1111
p.G696E	DO52732	CMDI	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.25
p.T679S	DO228945	LICA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1667
p.H694L	DO228960	LICA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.3056
p.E56G	DO229055	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.7199
p.A693D	DO229275	THCA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.6682
p.R686W	SIDM00973	Melanoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM01002	Breast Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM01041	Esophageal Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM00523	Small Cell Lung Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM01051	Ovarian Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM00181	Bladder Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM00462	Acute Myeloid Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM00665	Gastric Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.R686W	SIDM01646	Non-Cancerous	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.8634
p.A677T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1111
p.A677T	ACH-000995	Leukemia	CCLE	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1111
p.A677T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1111
p.P67H	SIDM00120	Prostate Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.P67H	ACH-000979	Prostate Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.P67H	DU-145	prostate	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.P695S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.2778
p.P695S	SIDM01653	Non-Cancerous	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.2778
p.P695S	SIDM00207	Glioblastoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.2778
p.G698A	SIDM01044	Other Solid Cancers	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1944
p.G698A	EPLC-272H	lung	COSMIC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation rewiring degron network	0.1944
p.K49R	SIDM00534	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.25
p.K49R	ACH-000986	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.25
p.K49R	HT-115	large intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.25
p.T59S	ACH-002019	Cervical Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	56:60	Mutation altering degron motif	0.6005
p.R50W	ONS-76	central nervous system	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1667
p.R50W	RCC10RGB	kidney	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1667
p.Q67E	NCI-H322M	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.Q67E	SCC-15	upper aerodigestive tract	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1389
p.S65I	Farage	haematopoietic and lymphoid tissue	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.1944
p.R48C	HCT-15	large intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation substituting flanking lysine	0.2222
p.A53T	NB69	autonomic ganglia	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.25
p.L66P	SCC-15	upper aerodigestive tract	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation blocking phosphorylation signal	0.6111
p.L66P	NCI-H322M	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation blocking phosphorylation signal	0.6111
p.G686A	EPLC-272H	lung	COSMIC	LRAQLSLMA	DEG_APCC_DBOX_1	685:693	Mutation altering degron motif	0.754
p.P55H	DU-145	prostate	COSMIC	PETTT	DEG_SPOP_SBC_1	56:60	Mutation rewiring degron network	0.3056

Kaplan plot for GOLGA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GOLGA2

UniProt ID: Q08379

Entrez ID: 2801

Protein name: Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GOLGA2 in