DegronMD

Uniprot ID: Q08379

Source protein: Golgin subfamily A member 2

Source gene: GOLGA2

Class: DEG_SPOP_SBC_1

Location: 56:60

E3 ligase: SPOP

DEGRON score: 0.8756

ASA_SCORE: 95.68

COIL: 0.8

CONS_SCORE: 0.3996

DSS_SCORE: 0.708

HELIX: 0.0224

FCONS_SCORE: 1.0167

RIG_SCORE: 0.5585

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K48N	TCGA-50-5946	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.2222
p.K48N	TCGA-55-A4DF	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.2222
p.K48N	SIDM01588	Endometrial Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.2222
p.K48N	ACH-000993	Endometrial/Uterine Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.2222
p.K47R	TCGA-AA-3713	COAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1944
p.K47R	DO8400	COAD	ICGC	PETTT	DEG_SPOP_SBC_1	0.1944
p.T70I	TCGA-DF-A2KU	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	0.0556
p.T70I	DO223286	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	0.0556
p.K46R	TCGA-F1-6874	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	0.1667
p.E57K	TCGA-XF-AAML	BLCA	TCGA	PETTT	DEG_SPOP_SBC_1	0.591
p.E56G	DO229055	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	0.7199
p.P67H	SIDM00120	Prostate Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.1389
p.P67H	ACH-000979	Prostate Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.1389
p.P67H	DU-145	prostate	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1389
p.K49R	SIDM00534	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	0.25
p.K49R	ACH-000986	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.25
p.K49R	HT-115	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.25
p.T59S	ACH-002019	Cervical Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	0.6005
p.R50W	ONS-76	central_nervous_system	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1667
p.R50W	RCC10RGB	kidney	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1667
p.Q67E	NCI-H322M	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1389
p.Q67E	SCC-15	upper_aerodigestive_tract	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1389
p.S65I	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PETTT	DEG_SPOP_SBC_1	0.1944
p.R48C	HCT-15	large_intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	0.2222
p.A53T	NB69	autonomic_ganglia	COSMIC	PETTT	DEG_SPOP_SBC_1	0.25
p.L66P	SCC-15	upper_aerodigestive_tract	COSMIC	PETTT	DEG_SPOP_SBC_1	0.6111
p.L66P	NCI-H322M	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	0.6111
p.P55H	DU-145	prostate	COSMIC	PETTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94817	Ubiquitin-like protein ATG12	DEG_SPOP_SBC_1	27:31	PETTT	SPOP	0.8998	More...
P07498	Kappa-casein	DEG_SPOP_SBC_1	170:174	PETTT	SPOP	0.991	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1844:1848	PETTT	SPOP	0.7668	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	1263:1267	PETTT	SPOP	0.74	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	984:988	PETTT	SPOP	0.91	More...
Q08379	Golgin subfamily A member 2	DEG_SPOP_SBC_1	56:60	PETTT	SPOP	0.8756	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11177:11181	PETTT	SPOP	0.6393	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11429:11433	PETTT	SPOP	0.8471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	928:932	PETTT	SPOP	0.9958	More...
Q9NYA3	Golgin subfamily A member 6A	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.6277	More...
Q9UHW9	Solute carrier family 12 member 6	DEG_SPOP_SBC_1	4:8	PETTT	SPOP	0.9865	More...
Q8N9W4	Golgin subfamily A member 6-like protein 2	DEG_SPOP_SBC_1	58:62	PETTT	SPOP	0.9524	More...
A6NDN3	Golgin subfamily A member 6B	DEG_SPOP_SBC_1	55:59	PETTT	SPOP	0.9725	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	602:606	PETTT	SPOP	0.8571	More...
Q63HN1	Putative protein FAM205B	DEG_SPOP_SBC_1	292:296	PETTT	SPOP	0.5845	More...
Q6ZU69	Protein FAM205A	DEG_SPOP_SBC_1	562:566	PETTT	SPOP	0.6816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETTT

Degron related mutations and impact score

Drug responses associated with GOLGA2 mutations

All proteins holding degron of PETTT