DegronMD - Q9UHW9(SLC12A6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E138K	TCGA-18-3409	LUSC	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.7022
p.E137Q	TCGA-66-2742	LUSC	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.5633
p.N132H	TCGA-A5-A0G2	UCEC	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.3056
p.F136S	TCGA-A5-A0GP	UCEC	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.7982
p.E137K	TCGA-AR-A2LH	BRCA	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.591
p.P4Q	TCGA-D3-A2JP	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7035
p.P4Q	DO47407	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7035
p.E127K	TCGA-DR-A0ZM	CESC	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1667
p.E127K	TCGA-HC-7077	PRAD	TCGA	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1667
p.F15L	TCGA-E5-A4TZ	BLCA	TCGA	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.F15L	DO44055	BLCA	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.P4L	TCGA-EE-A180	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7582
p.P4L	DO47537	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7582
p.K9N	TCGA-EY-A1GI	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.K9N	DO41211	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.R14Q	TCGA-F1-6874	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1667
p.R14Q	DO38201	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1667
p.R148H	DO219012	BLCA	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation blocking phosphorylation signal	0.5
p.A7V	DO219887	DLBC	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.6936
p.R148C	DO223068	ESCA	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation blocking phosphorylation signal	0.5
p.A17E	DO229022	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0833
p.A17E	DO229026	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.0833
p.P3H	DO229035	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.P12A	DO50974	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2222
p.M4K	DO231545	LINC	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.8062
p.G6R	DO45339	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7568
p.Y133C	DO26548	LUSC	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation altering degron motif	0.7087
p.T128I	DO232052	ORCA	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation blocking phosphorylation signal	0.6389
p.T128I	DO47337	SKCM	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation blocking phosphorylation signal	0.6389
p.M130I	DO47590	SKCM	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.25
p.G15V	DO229213	THCA	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.1389
p.M126R	DO41235	UCEC	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation rewiring degron network	0.1389
p.L145I	DO42713	UCEC	ICGC	LALFEE	LIG_APCC_ABBA_1	133:138	Mutation blocking ubiquitination signal	0.5833
p.V9A	DO41331	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.M10L	SIDM02026	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778

Kaplan plot for SLC12A6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC12A6

UniProt ID: Q9UHW9

Entrez ID: 9990

Protein name: Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC12A6 in