DegronMD

Uniprot ID: Q9UHW9

Source protein: Solute carrier family 12 member 6

Source gene: SLC12A6

Class: LIG_APCC_ABBA_1

Location: 133:138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9078

ASA_SCORE: 77.4167

COIL: 0.4765

CONS_SCORE: 0.3828

DSS_SCORE: 0.3676

HELIX: 0.4683

FCONS_SCORE: 1.1965

RIG_SCORE: 0.8296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E138K	TCGA-18-3409	LUSC	TCGA	LALFEE	LIG_APCC_ABBA_1	0.7022
p.E137Q	TCGA-66-2742	LUSC	TCGA	LALFEE	LIG_APCC_ABBA_1	0.5633
p.N132H	TCGA-A5-A0G2	UCEC	TCGA	LALFEE	LIG_APCC_ABBA_1	0.3056
p.F136S	TCGA-A5-A0GP	UCEC	TCGA	LALFEE	LIG_APCC_ABBA_1	0.7982
p.E137K	TCGA-AR-A2LH	BRCA	TCGA	LALFEE	LIG_APCC_ABBA_1	0.591
p.E127K	TCGA-DR-A0ZM	CESC	TCGA	LALFEE	LIG_APCC_ABBA_1	0.1667
p.E127K	TCGA-HC-7077	PRAD	TCGA	LALFEE	LIG_APCC_ABBA_1	0.1667
p.R148H	DO219012	BLCA	ICGC	LALFEE	LIG_APCC_ABBA_1	0.5
p.R148C	DO223068	ESCA	ICGC	LALFEE	LIG_APCC_ABBA_1	0.5
p.Y133C	DO26548	LUSC	ICGC	LALFEE	LIG_APCC_ABBA_1	0.7087
p.T128I	DO232052	ORCA	ICGC	LALFEE	LIG_APCC_ABBA_1	0.6389
p.T128I	DO47337	SKCM	ICGC	LALFEE	LIG_APCC_ABBA_1	0.6389
p.M130I	DO47590	SKCM	ICGC	LALFEE	LIG_APCC_ABBA_1	0.25
p.M126R	DO41235	UCEC	ICGC	LALFEE	LIG_APCC_ABBA_1	0.1389
p.L145I	DO42713	UCEC	ICGC	LALFEE	LIG_APCC_ABBA_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHW9	Solute carrier family 12 member 6	LIG_APCC_ABBA_1	133:138	LALFEE	APC,CDC20,FZR1	0.9078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons