DegronMD - Q9NYA3(GOLGA6A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A542V	TCGA-A5-A1OF	UCEC	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1389
p.A542V	DO42568	UCEC	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1389
p.S60C	TCGA-CV-7099	HNSC	TCGA	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.3056
p.S60C	DO15294	HNSC	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.3056
p.K48E	TCGA-D3-A8GI	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	55:59	Mutation blocking ubiquitination signal	0.5833
p.K48E	DO50284	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation blocking ubiquitination signal	0.5833
p.T545M	TCGA-D5-6532	COAD	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.2222
p.T545M	DO7890	COAD	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.2222
p.T545M	ACH-000988	Endometrial/Uterine Cancer	CCLE	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.2222
p.G61S	TCGA-EO-A22R	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2778
p.G61S	TCGA-G4-6586	COAD	TCGA	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2778
p.G61S	DO9698	COAD	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2778
p.G61S	DO42713	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2778
p.G61S	SIDM00318	Kidney Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2778
p.G564S	DO222610	COCA	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1389
p.D68V	DO222816	COCA	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.0833
p.G67E	DO229061	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1111
p.T58A	DO229062	LICA	ICGC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.7139
p.V556I	SIDM02039	Colorectal Carcinoma	GDSC	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation altering degron motif	0.5965
p.E56G	SIDM00357	Small Cell Lung Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation altering degron motif	0.6087
p.T51S	SIDM01664	Prostate Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2222
p.T51S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2222
p.R551Q	ACH-000334	Lymphoma	CCLE	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation altering degron motif	0.6218
p.P558A	ACH-000616	Gastric Cancer	CCLE	ERRELGFVQ	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GOLGA6A

UniProt ID: Q9NYA3

Entrez ID: 342096

Protein name: Golgin subfamily A member 6A (Golgin linked to PML) (Golgin-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GOLGA6A in