DegronMD

Uniprot ID: Q9NYA3

Source protein: Golgin subfamily A member 6A

Source gene: GOLGA6A

Class: DEG_APCC_DBOX_1

Location: 549:557

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8992

ASA_SCORE: 111.7

COIL: 0.4927

CONS_SCORE: 0.5899

DSS_SCORE: 0.6065

HELIX: 0.4953

FCONS_SCORE: 1.0546

RIG_SCORE: 0.7649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A542V	TCGA-A5-A1OF	UCEC	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389
p.A542V	DO42568	UCEC	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389
p.T545M	TCGA-D5-6532	COAD	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.2222
p.T545M	DO7890	COAD	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.2222
p.T545M	ACH-000988	Endometrial/Uterine Cancer	CCLE	ERRELGFVQ	DEG_APCC_DBOX_1	0.2222
p.G564S	DO222610	COCA	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389
p.V556I	SIDM02039	Colorectal Carcinoma	GDSC	ERRELGFVQ	DEG_APCC_DBOX_1	0.5965
p.R551Q	ACH-000334	Lymphoma	CCLE	ERRELGFVQ	DEG_APCC_DBOX_1	0.6218
p.P558A	ACH-000616	Gastric Cancer	CCLE	ERRELGFVQ	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons