DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERRELGFVQ
Uniprot ID:
A6NDK9
Source protein:
Golgin subfamily A member 6C
Source gene:
GOLGA6C
Class:
DEG_APCC_DBOX_1
Location:
549:557
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7385
ASA_SCORE:
111.8889
COIL:
0.5154
CONS_SCORE:
0.6097
DSS_SCORE:
0.6065
HELIX:
0.4633
FCONS_SCORE:
0.9967
RIG_SCORE:
0.7649
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M565I
DO225012
BRCA
ICGC
ERRELGFVQ
DEG_APCC_DBOX_1
0.1111
Drug responses associated with GOLGA6C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERRELGFVQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NYA3
Golgin subfamily A member 6A
DEG_APCC_DBOX_1
549:557
ERRELGFVQ
APC,CDC20,FZR1
0.8992
More...
A6NDN3
Golgin subfamily A member 6B
DEG_APCC_DBOX_1
549:557
ERRELGFVQ
APC,CDC20,FZR1
0.732
More...
A6NDK9
Golgin subfamily A member 6C
DEG_APCC_DBOX_1
549:557
ERRELGFVQ
APC,CDC20,FZR1
0.7385
More...
P0CG33
Golgin subfamily A member 6D
DEG_APCC_DBOX_1
549:557
ERRELGFVQ
APC,CDC20,FZR1
0.8495
More...