DegronMD

Uniprot ID: P0CG33

Source protein: Golgin subfamily A member 6D

Source gene: GOLGA6D

Class: DEG_APCC_DBOX_1

Location: 549:557

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8495

ASA_SCORE: 109.4444

COIL: 0.5038

CONS_SCORE: 0.6096

DSS_SCORE: 0.6065

HELIX: 0.4841

FCONS_SCORE: 0.9967

RIG_SCORE: 0.7649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R566K	TCGA-06-5416	GBM	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.0833
p.R566K	DO10880	GBM	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.0833
p.E540K	TCGA-91-6831	LUAD	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.0833
p.E540K	DO23753	LUAD	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.0833
p.G544R	TCGA-FW-A3R5	SKCM	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.1944
p.G544R	DO37406	SKCM	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.1944
p.V556I	TCGA-LN-A8HZ	ESCA	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.5965
p.G564S	TCGA-VQ-A8P2	STAD	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389
p.G564S	DO51761	STAD	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons