DegronMD

Uniprot ID: A6NDN3

Source protein: Golgin subfamily A member 6B

Source gene: GOLGA6B

Class: DEG_APCC_DBOX_1

Location: 549:557

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.732

ASA_SCORE: 111.6

COIL: 0.3766

CONS_SCORE: 0.5899

DSS_SCORE: 0.6065

HELIX: 0.6188

FCONS_SCORE: 1.0546

RIG_SCORE: 0.7649

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V556F	TCGA-21-1082	LUSC	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.7068
p.V556F	DO26463	LUSC	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.7068
p.V548M	TCGA-AA-A010	COAD	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.3056
p.G560E	TCGA-D3-A8GL	SKCM	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.25
p.G560E	DO50287	SKCM	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.25
p.G564S	TCGA-EB-A431	SKCM	TCGA	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389
p.G564S	DO37671	SKCM	ICGC	ERRELGFVQ	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons