DegronMD

Uniprot ID: Q08379

Source protein: Golgin subfamily A member 2

Source gene: GOLGA2

Class: DEG_APCC_DBOX_1

Location: 685:693

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5056

ASA_SCORE: 103.8556

COIL: 0.2461

CONS_SCORE: 0.5069

DSS_SCORE: 0.6983

HELIX: 0.7524

FCONS_SCORE: 1.0321

RIG_SCORE: 0.6762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A693T	TCGA-19-5956	GBM	TCGA	LRAQLSLMA	DEG_APCC_DBOX_1	0.6028
p.A693T	DO13863	GBM	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.6028
p.R703Q	TCGA-DF-A2KU	UCEC	TCGA	LRAQLSLMA	DEG_APCC_DBOX_1	0.0556
p.R703Q	DO223286	UCEC	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.0556
p.L701V	DO224667	BRCA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.1111
p.G696E	DO52732	CMDI	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.25
p.T679S	DO228945	LICA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.1667
p.H694L	DO228960	LICA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.3056
p.A693D	DO229275	THCA	ICGC	LRAQLSLMA	DEG_APCC_DBOX_1	0.6682
p.R686W	SIDM00973	Melanoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM01002	Breast Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM01041	Esophageal Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM00523	Small Cell Lung Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM01051	Ovarian Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM00181	Bladder Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM00462	Acute Myeloid Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM00665	Gastric Carcinoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.R686W	SIDM01646	Non-Cancerous	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.8634
p.A677T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.1111
p.A677T	ACH-000995	Leukemia	CCLE	LRAQLSLMA	DEG_APCC_DBOX_1	0.1111
p.A677T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LRAQLSLMA	DEG_APCC_DBOX_1	0.1111
p.P695S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.2778
p.P695S	SIDM01653	Non-Cancerous	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.2778
p.P695S	SIDM00207	Glioblastoma	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.2778
p.G698A	SIDM01044	Other Solid Cancers	GDSC	LRAQLSLMA	DEG_APCC_DBOX_1	0.1944
p.G698A	EPLC-272H	lung	COSMIC	LRAQLSLMA	DEG_APCC_DBOX_1	0.1944
p.G686A	EPLC-272H	lung	COSMIC	LRAQLSLMA	DEG_APCC_DBOX_1	0.754

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRAQLSLMA

Degron related mutations and impact score

Drug responses associated with GOLGA2 mutations

All proteins holding degron of LRAQLSLMA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08379	Golgin subfamily A member 2	DEG_APCC_DBOX_1	685:693	LRAQLSLMA	APC,CDC20,FZR1	0.5056	More...