DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: LIG_APCC_ABBA_1

Location: 1540:1545

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.806

ASA_SCORE: 88.1833

COIL: 0.845

CONS_SCORE: 0.5805

DSS_SCORE: 0.7019

HELIX: 0.0358

FCONS_SCORE: 1.1859

RIG_SCORE: 0.7025

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1532L	TCGA-49-AARE	LUAD	TCGA	VSLFPE	LIG_APCC_ABBA_1	0.1111
p.Q1532L	DO218922	LUAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1111
p.S1547C	TCGA-C8-A12P	BRCA	TCGA	VSLFPE	LIG_APCC_ABBA_1	0.2778
p.S1547C	DO4000	BRCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.2778
p.F1543L	TCGA-EO-A3B0	UCEC	TCGA	VSLFPE	LIG_APCC_ABBA_1	0.6981
p.F1543L	DO219773	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.6981
p.V1540F	DO219014	BLCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.5957
p.Y1533D	DO538	BLCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1389
p.V1548I	DO229340	BTCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.25
p.A1541T	DO10332	COAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.7139
p.G1543S	DO7825	COAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.6993
p.G1543S	DO230607	PRAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.6993
p.T1534M	DO227996	COCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1667
p.T1534M	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.1667
p.C1535Y	DO233154	GACA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.K1536N	DO13863	GBM	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.2222
p.K1536N	DO41379	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.2222
p.I1551T	DO228844	LICA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1667
p.G1549E	DO222494	MELA	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.2222
p.E1546K	DO36556	READ	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.3056
p.A1551S	DO220011	SARC	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1667
p.A1551S	DO41379	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.1667
p.G1555R	DO51761	STAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.0556
p.V1548L	DO40884	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	0.25
p.E1535G	SIDM00697	Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00395	Neuroblastoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00230	Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00523	Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00782	Colorectal Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00094	Kidney Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00852	Glioma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM00701	Non-Cancerous	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.E1535G	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.1944
p.D1554N	SIDM01090	Colorectal Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.0833
p.D1554N	ACH-000943	Colon/Colorectal Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	0.0833
p.D1554N	RKO	large_intestine	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.0833
p.P1544S	SIDM00007	Other Solid Cancers	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.5641
p.P1544S	ACH-001550	Skin Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	0.5641
p.P1544S	MCC13	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.5641
p.P1544L	SIDM00007	Other Solid Cancers	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.6471
p.P1544L	ACH-001550	Skin Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	0.6471
p.P1544L	MCC13	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.6471
p.E1545D	SIDM01052	Ovarian Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	0.5647
p.E1545D	ACH-000308	Ovarian Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	0.5647
p.E1545D	EFO-21	ovary	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.5647
p.K1546Q	MCC13	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.3056
p.F1554L	PC-3	prostate	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.0833
p.G1541R	Hs939-T	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.7568
p.R1536C	COLO-792	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.2222
p.K1547E	M14	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.2778
p.P1553S	MFE-296	endometrium	COSMIC	VSLFPE	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSLFPE

Degron related mutations and impact score

Drug responses associated with VCAN mutations

All proteins holding degron of VSLFPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	LIG_APCC_ABBA_1	1540:1545	VSLFPE	APC,CDC20,FZR1	0.806	More...