DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: LIG_APCC_ABBA_1

Location: 1870:1875

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6578

ASA_SCORE: 96.7

COIL: 0.7495

CONS_SCORE: 0.4403

DSS_SCORE: 0.485

HELIX: 0.0223

FCONS_SCORE: 0.9334

RIG_SCORE: 0.7497

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1863K	TCGA-AG-A002	READ	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.E1863K	TCGA-D1-A17Q	UCEC	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.E1863K	TCGA-ZF-AA4X	BLCA	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.E1863K	DO219091	BLCA	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.E1863K	DO41903	UCEC	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.G1868D	TCGA-AP-A059	UCEC	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.2778
p.G1868D	DO41361	UCEC	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.2778
p.P1872L	TCGA-DF-A2KU	UCEC	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.6471
p.P1872L	DO223286	UCEC	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.6471
p.P1872L	SIDM00957	Colorectal Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	0.6471
p.P1872L	SIDM01727	Chronic Myelogenous Leukemia	GDSC	LSPHVE	LIG_APCC_ABBA_1	0.6471
p.P1872L	COLO-678	large_intestine	COSMIC	LSPHVE	LIG_APCC_ABBA_1	0.6471
p.E1865K	TCGA-EE-A181	SKCM	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.E1865K	TCGA-QB-AA9O	SKCM	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.E1865K	DO37444	SKCM	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.E1865K	DO51267	SKCM	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.I1860S	TCGA-F5-6814	READ	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.0556
p.I1860S	DO36556	READ	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.0556
p.H1873R	TCGA-VQ-A924	STAD	TCGA	LSPHVE	LIG_APCC_ABBA_1	0.8244
p.H1873R	DO51795	STAD	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.8244
p.E1865D	DO51493	PACA	ICGC	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.P1882Q	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.P1882Q	ACH-000860	Lung Cancer	CCLE	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.P1882Q	NCI-H358	lung	COSMIC	LSPHVE	LIG_APCC_ABBA_1	0.1389
p.H1873Q	SIDM00803	Kidney Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	0.7582
p.H1873Q	ACH-000411	Kidney Cancer	CCLE	LSPHVE	LIG_APCC_ABBA_1	0.7582
p.H1873Q	769-P	kidney	COSMIC	LSPHVE	LIG_APCC_ABBA_1	0.7582
p.E1865G	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.E1865G	H3255	lung	COSMIC	LSPHVE	LIG_APCC_ABBA_1	0.1944
p.S1869L	COLO-678	large_intestine	COSMIC	LSPHVE	LIG_APCC_ABBA_1	0.3056
p.V1867I	RL95-2	endometrium	COSMIC	LSPHVE	LIG_APCC_ABBA_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSPHVE

Degron related mutations and impact score

Drug responses associated with VCAN mutations

All proteins holding degron of LSPHVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	LIG_APCC_ABBA_1	1870:1875	LSPHVE	APC,CDC20,FZR1	0.6578	More...