DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SCF_FBW7_2

Location: 1060:1065

E3 ligase: FBXW7

DEGRON score: 0.7829

ASA_SCORE: 94.6167

COIL: 0.8217

CONS_SCORE: 0.3736

DSS_SCORE: 0.6671

HELIX: 0.0478

FCONS_SCORE: 0.8283

RIG_SCORE: 0.7273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1057N	TCGA-AX-A2HC	UCEC	TCGA	VTPLDE	DEG_SCF_FBW7_2	0.3611
p.K1057N	DO41572	UCEC	ICGC	VTPLDE	DEG_SCF_FBW7_2	0.3611
p.D1069N	TCGA-BF-A1PU	SKCM	TCGA	VTPLDE	DEG_SCF_FBW7_2	0.2222
p.D1069N	TCGA-CV-6938	HNSC	TCGA	VTPLDE	DEG_SCF_FBW7_2	0.2222
p.D1069N	TCGA-XF-A9SU	BLCA	TCGA	VTPLDE	DEG_SCF_FBW7_2	0.2222
p.D1069N	DO223600	BLCA	ICGC	VTPLDE	DEG_SCF_FBW7_2	0.2222
p.D1069N	DO14462	HNSC	ICGC	VTPLDE	DEG_SCF_FBW7_2	0.2222
p.D1069N	DO50278	SKCM	ICGC	VTPLDE	DEG_SCF_FBW7_2	0.2222
p.E1058K	TCGA-QB-A6FS	SKCM	TCGA	VTPLDE	DEG_SCF_FBW7_2	0.2778
p.E1058K	DO48654	SKCM	ICGC	VTPLDE	DEG_SCF_FBW7_2	0.2778
p.A1053S	DO233951	GACA	ICGC	VTPLDE	DEG_SCF_FBW7_2	0.1389
p.L1063P	SIDM00871	Non-Cancerous	GDSC	VTPLDE	DEG_SCF_FBW7_2	0.6471
p.L1063P	SIDM00872	Breast Carcinoma	GDSC	VTPLDE	DEG_SCF_FBW7_2	0.6471
p.V1061A	NCI-H748	lung	COSMIC	VTPLDE	DEG_SCF_FBW7_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SCF_FBW7_2	1060:1065	VTPLDE	FBXW7	0.7829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons