DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: LIG_APCC_ABBA_1

Location: 2489:2494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5237

ASA_SCORE: 93.7833

COIL: 0.8388

CONS_SCORE: 0.3687

DSS_SCORE: 0.5888

HELIX: 0.0268

FCONS_SCORE: 0.8581

RIG_SCORE: 0.7089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2498N	TCGA-AX-A05Z	UCEC	TCGA	LPLHSE	LIG_APCC_ABBA_1	0.2222
p.S2498N	DO40884	UCEC	ICGC	LPLHSE	LIG_APCC_ABBA_1	0.2222
p.E2494K	TCGA-CV-7568	HNSC	TCGA	LPLHSE	LIG_APCC_ABBA_1	0.7022
p.E2494K	DO14160	HNSC	ICGC	LPLHSE	LIG_APCC_ABBA_1	0.7022
p.T2503A	TCGA-DM-A1DA	COAD	TCGA	LPLHSE	LIG_APCC_ABBA_1	0.0833
p.T2503A	DO7852	COAD	ICGC	LPLHSE	LIG_APCC_ABBA_1	0.0833
p.S2486L	TCGA-EO-A22X	UCEC	TCGA	LPLHSE	LIG_APCC_ABBA_1	0.25
p.S2486L	DO43907	UCEC	ICGC	LPLHSE	LIG_APCC_ABBA_1	0.25
p.N2496D	TCGA-HU-8602	STAD	TCGA	LPLHSE	LIG_APCC_ABBA_1	0.2778
p.N2496D	DO47829	STAD	ICGC	LPLHSE	LIG_APCC_ABBA_1	0.2778
p.S2504N	SIDM01169	Ovarian Carcinoma	GDSC	LPLHSE	LIG_APCC_ABBA_1	0.0556
p.S2504N	ACH-000885	Ovarian Cancer	CCLE	LPLHSE	LIG_APCC_ABBA_1	0.0556
p.S2504N	TOV-21G	ovary	COSMIC	LPLHSE	LIG_APCC_ABBA_1	0.0556
p.S2498I	SIDM01113	Other Sarcomas	GDSC	LPLHSE	LIG_APCC_ABBA_1	0.2222
p.S2498I	SK-UT-1	soft_tissue	COSMIC	LPLHSE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	LIG_APCC_ABBA_1	2489:2494	LPLHSE	APC,CDC20,FZR1	0.5237	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons