DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_COP1_1

Location: 2789:2798

E3 ligase: COP1

DEGRON score: 0.6898

ASA_SCORE: 92.88

COIL: 0.7293

CONS_SCORE: 0.4229

DSS_SCORE: 0.4608

HELIX: 0.0233

FCONS_SCORE: 0.944

RIG_SCORE: 0.7823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2787F	TCGA-17-Z045	LUAD	TCGA	DQSVTEVPDV	DEG_COP1_1	0.2778
p.E2794Q	TCGA-44-2656	LUAD	TCGA	DQSVTEVPDV	DEG_COP1_1	0.5633
p.E2794Q	DO26052	LUAD	ICGC	DQSVTEVPDV	DEG_COP1_1	0.5633
p.E2800D	TCGA-66-2767	LUSC	TCGA	DQSVTEVPDV	DEG_COP1_1	0.2778
p.E2800D	DO26713	LUSC	ICGC	DQSVTEVPDV	DEG_COP1_1	0.2778
p.D2789Y	TCGA-AX-A1CE	UCEC	TCGA	DQSVTEVPDV	DEG_COP1_1	0.7325
p.D2789Y	DO42280	UCEC	ICGC	DQSVTEVPDV	DEG_COP1_1	0.7325
p.M2788I	TCGA-BF-A1PZ	SKCM	TCGA	DQSVTEVPDV	DEG_COP1_1	0.3056
p.M2788I	DO50279	SKCM	ICGC	DQSVTEVPDV	DEG_COP1_1	0.3056
p.M2799T	TCGA-BH-A0EE	BRCA	TCGA	DQSVTEVPDV	DEG_COP1_1	0.3056
p.M2799T	DO6088	BRCA	ICGC	DQSVTEVPDV	DEG_COP1_1	0.3056
p.S2802T	TCGA-D5-6931	COAD	TCGA	DQSVTEVPDV	DEG_COP1_1	0.2222
p.S2802T	DO8384	COAD	ICGC	DQSVTEVPDV	DEG_COP1_1	0.2222
p.D2797H	TCGA-DK-A6B5	BLCA	TCGA	DQSVTEVPDV	DEG_COP1_1	0.7688
p.D2797H	DO48551	BLCA	ICGC	DQSVTEVPDV	DEG_COP1_1	0.7688
p.I2782V	TCGA-IB-7651	PAAD	TCGA	DQSVTEVPDV	DEG_COP1_1	0.1389
p.I2782V	DO46657	PAAD	ICGC	DQSVTEVPDV	DEG_COP1_1	0.1389
p.N2803S	TCGA-S8-A6BW	ESCA	TCGA	DQSVTEVPDV	DEG_COP1_1	0.1944
p.H2786L	DO52492	COCA	ICGC	DQSVTEVPDV	DEG_COP1_1	0.25
p.H2786Q	DO224563	LUSC	ICGC	DQSVTEVPDV	DEG_COP1_1	0.25
p.M2799I	DO222843	MELA	ICGC	DQSVTEVPDV	DEG_COP1_1	0.3056
p.S2802F	DO219878	SKCA	ICGC	DQSVTEVPDV	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_COP1_1	2789:2798	DQSVTEVPDV	COP1	0.6898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons