DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NGLESYTTLP
Uniprot ID:
P13611
Source protein:
Versican core protein
Source gene:
VCAN
Class:
CBL_PTK
Location:
2188:2197
E3 ligase:
CBL
DEGRON score:
0.7999
ASA_SCORE:
86.1
COIL:
0.6993
CONS_SCORE:
0.3832
DSS_SCORE:
0.5821
HELIX:
0.0188
FCONS_SCORE:
0.8824
RIG_SCORE:
0.7163
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P2185Q
TCGA-39-5034
LUSC
TCGA
NGLESYTTLP
CBL_PTK
0.25
p.P2185Q
DO26854
LUSC
ICGC
NGLESYTTLP
CBL_PTK
0.25
p.G2189D
TCGA-AP-A056
UCEC
TCGA
NGLESYTTLP
CBL_PTK
0.6087
p.G2189D
DO43971
UCEC
ICGC
NGLESYTTLP
CBL_PTK
0.6087
p.P2197T
TCGA-IB-7651
PAAD
TCGA
NGLESYTTLP
CBL_PTK
0.7031
p.P2197T
DO46657
PAAD
ICGC
NGLESYTTLP
CBL_PTK
0.7031
p.P2183S
TCGA-W3-AA1V
SKCM
TCGA
NGLESYTTLP
CBL_PTK
0.1944
p.P2183S
DO51276
SKCM
ICGC
NGLESYTTLP
CBL_PTK
0.1944
p.P2183L
TCGA-W3-AA1V
SKCM
TCGA
NGLESYTTLP
CBL_PTK
0.1944
p.P2183L
DO51276
SKCM
ICGC
NGLESYTTLP
CBL_PTK
0.1944
p.K2202N
DO228948
LICA
ICGC
NGLESYTTLP
CBL_PTK
0.3056
p.E2191K
DO34448
PACA
ICGC
NGLESYTTLP
CBL_PTK
0.591
Drug responses associated with VCAN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGLESYTTLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
CBL_PTK
2188:2197
NGLESYTTLP
CBL
0.7999
More...
