DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SCF_FBW7_1

Location: 423:429

E3 ligase: FBXW7

DEGRON score: 0.9843

ASA_SCORE: 74.7857

COIL: 0.9337

CONS_SCORE: 0.3615

DSS_SCORE: 0.5672

HELIX: 0.0151

FCONS_SCORE: 0.9779

RIG_SCORE: 0.6477

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K431T	TCGA-D7-A4Z0	STAD	TCGA	LPTPTGS	DEG_SCF_FBW7_1	0.2778
p.K431T	DO47765	STAD	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.2778
p.K431N	TCGA-F5-6814	READ	TCGA	LPTPTGS	DEG_SCF_FBW7_1	0.2778
p.K431N	DO36556	READ	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.2778
p.L423S	TCGA-VQ-A8P5	STAD	TCGA	LPTPTGS	DEG_SCF_FBW7_1	0.7667
p.L423S	DO51763	STAD	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.7667
p.Q413K	DO48366	BLCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.0556
p.G428D	DO229005	COCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.6087
p.G428D	DO229505	LAML	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.6087
p.G428D	DO229047	LICA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.6087
p.G428D	DO230550	LUSC	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.6087
p.D435N	DO222875	MELA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.1667
p.P433F	DO222843	MELA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.2222
p.A414V	DO228138	PBCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.0833
p.P433L	DO218908	SKCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	0.2222
p.T416A	SIDM00107	Melanoma	GDSC	LPTPTGS	DEG_SCF_FBW7_1	0.1389
p.T416A	SIDM00282	Colorectal Carcinoma	GDSC	LPTPTGS	DEG_SCF_FBW7_1	0.1389
p.T416A	ACH-000998	Colon/Colorectal Cancer	CCLE	LPTPTGS	DEG_SCF_FBW7_1	0.1389
p.T416A	CW-2	large_intestine	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.1389
p.T416A	UACC-62	skin	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.1389
p.I415V	SIDM00493	Other Solid Cancers	GDSC	LPTPTGS	DEG_SCF_FBW7_1	0.1111
p.T427A	SIDM01588	Endometrial Carcinoma	GDSC	LPTPTGS	DEG_SCF_FBW7_1	0.6028
p.T427A	ACH-000993	Endometrial/Uterine Cancer	CCLE	LPTPTGS	DEG_SCF_FBW7_1	0.6028
p.S415R	ACH-001081	Colon/Colorectal Cancer	CCLE	LPTPTGS	DEG_SCF_FBW7_1	0.1111
p.S415R	HCC2998	large_intestine	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.1111
p.V418I	HOP-62	lung	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.1944
p.T416I	RERF-LC-Sq1	lung	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.1389
p.V430I	EFO-27	ovary	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.3056
p.E437Q	NCI-H520	lung	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPTGS

Degron related mutations and impact score

Drug responses associated with VCAN mutations

All proteins holding degron of LPTPTGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SCF_FBW7_1	423:429	LPTPTGS	FBXW7	0.9843	More...