DegronMD

Uniprot ID: Q96T23

Source protein: Remodeling and spacing factor 1

Source gene: RSF1

Class: DEG_APCC_KENBOX_2

Location: 315:319

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9359

ASA_SCORE: 107.44

COIL: 0.691

CONS_SCORE: 0.3899

DSS_SCORE: 0.3761

HELIX: 0.2536

FCONS_SCORE: 0.9968

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I307S	TCGA-AP-A1DV	UCEC	TCGA	FKENV	DEG_APCC_KENBOX_2	0.1111
p.R326H	DO10020	COAD	ICGC	FKENV	DEG_APCC_KENBOX_2	0.1389
p.R326C	DO233156	GACA	ICGC	FKENV	DEG_APCC_KENBOX_2	0.1389
p.K313I	DO219129	LUSC	ICGC	FKENV	DEG_APCC_KENBOX_2	0.2778
p.K320N	DO43971	UCEC	ICGC	FKENV	DEG_APCC_KENBOX_2	0.75
p.V324A	SIDM01138	Pancreatic Carcinoma	GDSC	FKENV	DEG_APCC_KENBOX_2	0.1944
p.V324A	ACH-000139	Pancreatic Cancer	CCLE	FKENV	DEG_APCC_KENBOX_2	0.1944
p.V324A	PANC-03-27	pancreas	COSMIC	FKENV	DEG_APCC_KENBOX_2	0.1944
p.S318F	SNU-81	large_intestine	COSMIC	FKENV	DEG_APCC_KENBOX_2	0.7982
p.S306F	H290	pleura	COSMIC	FKENV	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T23	Remodeling and spacing factor 1	DEG_APCC_KENBOX_2	315:319	FKENV	APC,CDC20,FZR1	0.9359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons