DegronMD

Uniprot ID: Q96T23

Source protein: Remodeling and spacing factor 1

Source gene: RSF1

Class: DEG_APCC_DBOX_1

Location: 1087:1095

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9973

ASA_SCORE: 127.2889

COIL: 0.5617

CONS_SCORE: 0.4804

DSS_SCORE: 0.5569

HELIX: 0.4199

FCONS_SCORE: 1.2425

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1089Q	TCGA-42-2593	OV	TCGA	KRRRLNDLD	DEG_APCC_DBOX_1	0.6218
p.R1084Q	TCGA-AX-A2HA	UCEC	TCGA	KRRRLNDLD	DEG_APCC_DBOX_1	0.25
p.R1088H	TCGA-BS-A0TJ	UCEC	TCGA	KRRRLNDLD	DEG_APCC_DBOX_1	0.8244
p.E1092Q	DO534	BLCA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	0.6744
p.E1100Q	DO233672	GACA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	0.1944
p.Q1082K	DO228978	LICA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	0.1944
p.P1088S	DO219878	SKCA	ICGC	KRRRLNDLD	DEG_APCC_DBOX_1	0.6752
p.R1079G	ACH-000390	Lung Cancer	CCLE	KRRRLNDLD	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T23	Remodeling and spacing factor 1	DEG_APCC_DBOX_1	1087:1095	KRRRLNDLD	APC,CDC20,FZR1	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons