DegronMD

Uniprot ID: Q12889

Source protein: Oviduct-specific glycoprotein

Source gene: OVGP1

Class: DEG_SCF_FBW7_1

Location: 442:449

E3 ligase: FBXW7

DEGRON score: 0.6744

ASA_SCORE: 73.5125

COIL: 0.6004

CONS_SCORE: 0.6149

DSS_SCORE: 0.549

HELIX: 0.0111

FCONS_SCORE: 0.9981

RIG_SCORE: 0.7385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E440A	TCGA-AG-A002	READ	TCGA	MTITPRGT	DEG_SCF_FBW7_1	0.2778
p.S459F	TCGA-CV-A468	HNSC	TCGA	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.S459F	TCGA-D3-A3ML	SKCM	TCGA	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.S459F	TCGA-FW-A3R5	SKCM	TCGA	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.S459F	DO52070	HNSC	ICGC	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.S459F	DO37406	SKCM	ICGC	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.S459F	DO47413	SKCM	ICGC	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.S459F	ACH-001567	Skin Cancer	CCLE	MTITPRGT	DEG_SCF_FBW7_1	0.0556
p.G448D	TCGA-ER-A19H	SKCM	TCGA	MTITPRGT	DEG_SCF_FBW7_1	0.6087
p.G448D	DO47299	SKCM	ICGC	MTITPRGT	DEG_SCF_FBW7_1	0.6087
p.T457I	DO23548	LIRI	ICGC	MTITPRGT	DEG_SCF_FBW7_1	0.1111
p.M442R	DO220877	MELA	ICGC	MTITPRGT	DEG_SCF_FBW7_1	0.8632
p.N441K	SIDM01191	Osteosarcoma	GDSC	MTITPRGT	DEG_SCF_FBW7_1	0.3056
p.N441K	ACH-000364	Primary	CCLE	MTITPRGT	DEG_SCF_FBW7_1	0.3056
p.N441K	U-2-OS	bone	COSMIC	MTITPRGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12889	Oviduct-specific glycoprotein	DEG_SCF_FBW7_1	442:449	MTITPRGT	FBXW7	0.6744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons