DegronMD - O14924(RGS12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1126T	TCGA-AX-A1CE	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.3056
p.A1126T	DO42280	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.3056
p.T1137M	TCGA-CG-5726	STAD	TCGA	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1667
p.T1137M	DO38483	STAD	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1667
p.N1124S	DO229346	LAML	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.25
p.N1124S	DO229047	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.25
p.N1124S	DO230541	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.25
p.N1124S	DO52365	LUSC	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.25
p.E1139D	DO228952	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1111
p.V1121L	DO229008	LICA	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1667
p.V1121L	SIDM00503	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1667
p.V1121L	SIDM01770	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1667
p.V1121L	FU97	stomach	COSMIC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1667
p.A1126G	DO228338	MALY	ICGC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.3056
p.A1126G	SIDM00948	Burkitt's Lymphoma	GDSC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.3056
p.A1126G	ACH-002232	Lymphoma	CCLE	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.3056
p.A1126G	DG-75	haematopoietic and lymphoid tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.3056
p.P1120L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1389

Kaplan plot for RGS12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS12

UniProt ID: O14924

Entrez ID: 6002

Protein name: Regulator of G-protein signaling 12 (RGS12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS12 in