DegronMD

Uniprot ID: P51522

Source protein: Zinc finger protein 83

Source gene: ZNF83

Class: DEG_SPOP_SBC_1

Location: 47:51

E3 ligase: SPOP

DEGRON score: 0.6424

ASA_SCORE: 63.02

COIL: 0.6698

CONS_SCORE: 0.3949

DSS_SCORE: 0.4837

HELIX: 0.0924

FCONS_SCORE: 0.7625

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R58H	TCGA-AA-3492	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58H	DO8224	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58H	ACH-000960	Leukemia	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58H	ACH-001959	Bile Duct Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.H42R	TCGA-AP-A051	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1944
p.H42R	DO42673	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1944
p.S50C	TCGA-ER-A19F	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7541
p.S50C	DO37679	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7541
p.E54K	DO228627	GACA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.25
p.E39K	DO222595	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.2222
p.D50A	DO232224	PBCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7793
p.R58S	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58S	ACH-000665	Lung Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.1389
p.R58S	SK-MES-1	lung	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.1389
p.V47L	SIDM01199	Hepatocellular Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.6765
p.V47L	ACH-000493	Liver Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.6765
p.V47L	SNU-423	liver	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.6765
p.S46A	SIDM00778	Colorectal Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.3056
p.S46A	ACH-000403	Colon/Colorectal Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.3056
p.S46A	NCI-H747	large_intestine	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons