DegronMD

Uniprot ID: P21453

Source protein: Sphingosine 1-phosphate receptor 1

Source gene: S1PR1

Class: DEG_SPOP_SBC_1

Location: 378:382

E3 ligase: SPOP

DEGRON score: 0.977

ASA_SCORE: 118.7

COIL: 0.9886

CONS_SCORE: 0.6207

DSS_SCORE: 0.9534

HELIX: 0.0084

FCONS_SCORE: 1.1736

RIG_SCORE: 0.5929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V378I	TCGA-AG-A00Y	READ	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7076
p.V378I	DO222445	BTCA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7076
p.V378I	DO36542	READ	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7076
p.S382F	TCGA-DA-A3F8	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7982
p.S382F	TCGA-EB-A3Y7	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.7982
p.S382F	DO37418	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7982
p.S382F	DO37499	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.7982
p.E370A	TCGA-Z2-AA3S	SKCM	TCGA	VNSSS	DEG_SPOP_SBC_1	0.1111
p.E370A	DO51302	SKCM	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.S380P	DO218243	GACA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.6752
p.E370Q	DO23170	LINC	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.E370K	DO220911	MELA	ICGC	VNSSS	DEG_SPOP_SBC_1	0.1111
p.S380Y	SIDM00279	Gastric Carcinoma	GDSC	VNSSS	DEG_SPOP_SBC_1	0.712
p.S380Y	ACH-000225	Gastric Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	0.712
p.S380Y	ECC12	stomach	COSMIC	VNSSS	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14924	Regulator of G-protein signaling 12	DEG_SPOP_SBC_1	1127:1131	VNSSS	SPOP	0.8442	More...
P06241	Tyrosine-protein kinase Fyn	DEG_SPOP_SBC_1	67:71	VNSSS	SPOP	0.9672	More...
P21453	Sphingosine 1-phosphate receptor 1	DEG_SPOP_SBC_1	378:382	VNSSS	SPOP	0.977	More...
Q12889	Oviduct-specific glycoprotein	DEG_SPOP_SBC_1	401:405	VNSSS	SPOP	0.965	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	197:201	VNSSS	SPOP	0.9915	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	342:346	VNSSS	SPOP	0.968	More...
Q5TB80	Centrosomal protein of 162 kDa	DEG_SPOP_SBC_1	454:458	VNSSS	SPOP	0.8991	More...
Q7L4E1	Mitoguardin 2	DEG_SPOP_SBC_1	144:148	VNSSS	SPOP	0.9606	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5227:5231	VNSSS	SPOP	0.8577	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	574:578	VNSSS	SPOP	0.9912	More...
Q99598	Translin-associated protein X	DEG_SPOP_SBC_1	29:33	VNSSS	SPOP	0.9939	More...
A6NGB9	WAS/WASL-interacting protein family member 3	DEG_SPOP_SBC_1	316:320	VNSSS	SPOP	0.946	More...
P51522	Zinc finger protein 83	DEG_SPOP_SBC_1	47:51	VNSSS	SPOP	0.6424	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1624:1628	VNSSS	SPOP	0.9986	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	123:127	VNSSS	SPOP	0.7274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons