DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VNSSS
Uniprot ID:
P21453
Source protein:
Sphingosine 1-phosphate receptor 1
Source gene:
S1PR1
Class:
DEG_SPOP_SBC_1
Location:
378:382
E3 ligase:
SPOP
DEGRON score:
0.977
ASA_SCORE:
118.7
COIL:
0.9886
CONS_SCORE:
0.6207
DSS_SCORE:
0.9534
HELIX:
0.0084
FCONS_SCORE:
1.1736
RIG_SCORE:
0.5929
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S382F
TCGA-DA-A3F8
SKCM
TCGA
VNSSS
DEG_SPOP_SBC_1
0.7982
p.S382F
TCGA-EB-A3Y7
SKCM
TCGA
VNSSS
DEG_SPOP_SBC_1
0.7982
p.S382F
DO37418
SKCM
ICGC
VNSSS
DEG_SPOP_SBC_1
0.7982
p.S382F
DO37499
SKCM
ICGC
VNSSS
DEG_SPOP_SBC_1
0.7982
p.S380Y
SIDM00279
Gastric Carcinoma
GDSC
VNSSS
DEG_SPOP_SBC_1
0.712
p.S380Y
ACH-000225
Gastric Cancer
CCLE
VNSSS
DEG_SPOP_SBC_1
0.712
p.S380Y
ECC12
stomach
COSMIC
VNSSS
DEG_SPOP_SBC_1
0.712
p.V378I
TCGA-AG-A00Y
READ
TCGA
VNSSS
DEG_SPOP_SBC_1
0.7076
p.V378I
DO222445
BTCA
ICGC
VNSSS
DEG_SPOP_SBC_1
0.7076
p.V378I
DO36542
READ
ICGC
VNSSS
DEG_SPOP_SBC_1
0.7076
p.S380P
DO218243
GACA
ICGC
VNSSS
DEG_SPOP_SBC_1
0.6752
p.E370A
TCGA-Z2-AA3S
SKCM
TCGA
VNSSS
DEG_SPOP_SBC_1
0.1111
p.E370A
DO51302
SKCM
ICGC
VNSSS
DEG_SPOP_SBC_1
0.1111
p.E370Q
DO23170
LINC
ICGC
VNSSS
DEG_SPOP_SBC_1
0.1111
p.E370K
DO220911
MELA
ICGC
VNSSS
DEG_SPOP_SBC_1
0.1111
Showing 1 to 15 of 15 entries
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Drug responses associated with S1PR1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of VNSSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SQI0
Alpha-tubulin N-acetyltransferase 1
DEG_SPOP_SBC_1
342:346
VNSSS
SPOP
0.968
More...
Q96KQ4
Apoptosis-stimulating of p53 protein 1
DEG_SPOP_SBC_1
574:578
VNSSS
SPOP
0.9912
More...
Q58F21
Bromodomain testis-specific protein
DEG_SPOP_SBC_1
197:201
VNSSS
SPOP
0.9915
More...
Q5TB80
Centrosomal protein of 162 kDa
DEG_SPOP_SBC_1
454:458
VNSSS
SPOP
0.8991
More...
Q7L4E1
Mitoguardin 2
DEG_SPOP_SBC_1
144:148
VNSSS
SPOP
0.9606
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
5227:5231
VNSSS
SPOP
0.8577
More...
Q12889
Oviduct-specific glycoprotein
DEG_SPOP_SBC_1
401:405
VNSSS
SPOP
0.965
More...
O14924
Regulator of G-protein signaling 12
DEG_SPOP_SBC_1
1127:1131
VNSSS
SPOP
0.8442
More...
P21453
Sphingosine 1-phosphate receptor 1
DEG_SPOP_SBC_1
378:382
VNSSS
SPOP
0.977
More...
Q99598
Translin-associated protein X
DEG_SPOP_SBC_1
29:33
VNSSS
SPOP
0.9939
More...
Q92545
Transmembrane protein 131
DEG_SPOP_SBC_1
1624:1628
VNSSS
SPOP
0.9986
More...
A6NKL6
Transmembrane protein 200C
DEG_SPOP_SBC_1
123:127
VNSSS
SPOP
0.7274
More...
P06241
Tyrosine-protein kinase Fyn
DEG_SPOP_SBC_1
67:71
VNSSS
SPOP
0.9672
More...
A6NGB9
WAS/WASL-interacting protein family member 3
DEG_SPOP_SBC_1
316:320
VNSSS
SPOP
0.946
More...
P51522
Zinc finger protein 83
DEG_SPOP_SBC_1
47:51
VNSSS
SPOP
0.6424
More...
Showing 1 to 15 of 15 entries
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