DegronMD - P06241(FYN)

FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}. View more >>

GO - Biological processes (BP): activated T cell proliferation [GO:0050798]; adaptive immune response [GO:0002250]; axon guidance [GO:0007411]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cellular response to amyloid-beta [GO:1904646]; cellular response to glycine [GO:1905430]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to L-glutamate [GO:1905232]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; dendrite morphogenesis [GO:0048813]; dendritic spine maintenance [GO:0097062]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; heart process [GO:0003015]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; learning [GO:0007612]; leukocyte migration [GO:0050900]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of oxidative stress-induced cell death [GO:1903202]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein ubiquitination [GO:0031397]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein localization to membrane [GO:1905477]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of cell shape [GO:0008360]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to amyloid-beta [GO:1904645]; response to ethanol [GO:0045471]; response to singlet oxygen [GO:0000304]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell costimulation [GO:0031295]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G81R	TCGA-B5-A1MX	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.0556
p.G81R	DO41999	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.0556
p.T73M	TCGA-DK-A6AW	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2778
p.T73M	TCGA-EO-A22X	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2778
p.T73M	TCGA-EO-A3AZ	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2778
p.T73M	DO48566	BLCA	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2778
p.T73M	DO50078	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2778
p.T73M	DO43907	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2778
p.S70L	TCGA-DK-A6AW	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	TCGA-E6-A1LX	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	TCGA-EO-A3B0	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	DO48566	BLCA	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	DO219773	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	DO41020	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	SIDM01179	Other Sarcomas	GDSC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	ACH-001702	Sarcoma	CCLE	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S70L	VA-ES-BJ	bone	COSMIC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.7667
p.S69Y	TCGA-EO-A3B0	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.712
p.S69Y	DO219773	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation altering degron motif	0.712
p.R77C	TCGA-QG-A5Z2	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1667
p.R77C	DO44096	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1667
p.V63I	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2222
p.V63I	JVM-2	haematopoietic and lymphoid tissue	COSMIC	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.2222
p.R77H	ACH-001061	Colon/Colorectal Cancer	CCLE	VNSSS	DEG_SPOP_SBC_1	67:71	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FYN

UniProt ID: P06241

Entrez ID: 2534

Protein name: Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FYN in