DegronMD

Uniprot ID: A6NKL6

Source protein: Transmembrane protein 200C

Source gene: TMEM200C

Class: DEG_SPOP_SBC_1

Location: 543:547

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 65.42

COIL: 0.8564

CONS_SCORE: 0.5675

DSS_SCORE: 0.5831

HELIX: 0.0656

FCONS_SCORE: 1.1521

RIG_SCORE: 0.659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q557E	TCGA-UB-A7MF	LIHC	TCGA	AGTST	DEG_SPOP_SBC_1	0.0556
p.Q557E	DO52322	LIHC	ICGC	AGTST	DEG_SPOP_SBC_1	0.0556
p.A553S	TCGA-Z6-A8JE	ESCA	TCGA	AGTST	DEG_SPOP_SBC_1	0.1667
p.A553S	ACH-001370	Ovarian Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	0.1667
p.E548K	TCGA-ZX-AA5X	CESC	TCGA	AGTST	DEG_SPOP_SBC_1	0.3056
p.E548K	DO219762	CESC	ICGC	AGTST	DEG_SPOP_SBC_1	0.3056
p.S533R	DO222419	BTCA	ICGC	AGTST	DEG_SPOP_SBC_1	0.0556
p.R541W	DO233882	GACA	ICGC	AGTST	DEG_SPOP_SBC_1	0.2778
p.R541W	SIDM02039	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.2778
p.A555D	DO229015	LICA	ICGC	AGTST	DEG_SPOP_SBC_1	0.1111
p.R541Q	DO222632	MELA	ICGC	AGTST	DEG_SPOP_SBC_1	0.2778
p.R541Q	SIDM01203	Other Solid Cancers	GDSC	AGTST	DEG_SPOP_SBC_1	0.2778
p.R541Q	ACH-002291	Embryonal Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	0.2778
p.R541Q	NTERA-2_cl_D1	testis	COSMIC	AGTST	DEG_SPOP_SBC_1	0.2778
p.P539L	DO222837	MELA	ICGC	AGTST	DEG_SPOP_SBC_1	0.2222
p.S546C	SIDM01665	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	0.7541
p.S546C	ACH-000089	Colon/Colorectal Cancer	CCLE	AGTST	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2IDD5	Coiled-coil domain-containing protein 78	DEG_SPOP_SBC_1	432:436	AGTST	SPOP	0.8882	More...
O75165	DnaJ homolog subfamily C member 13	DEG_SPOP_SBC_1	2218:2222	AGTST	SPOP	0.9952	More...
O96008	Mitochondrial import receptor subunit TOM40 homolog	DEG_SPOP_SBC_1	46:50	AGTST	SPOP	0.8387	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3314:3318	AGTST	SPOP	0.9902	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	543:547	AGTST	SPOP	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons