DegronMD - O75165(DNAJC13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1605V	TCGA-56-8628	LUSC	TCGA	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.5965
p.I1605V	DO45433	LUSC	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.5965
p.I1605V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.5965
p.T2217I	TCGA-60-2698	LUSC	TCGA	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.3056
p.T2217I	DO26469	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.3056
p.G1611V	TCGA-A6-3809	COAD	TCGA	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.6421
p.G1611V	DO8722	COAD	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.6421
p.G2214D	TCGA-BR-6452	STAD	TCGA	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.2222
p.G2214D	DO38404	STAD	ICGC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.2222
p.R1606M	TCGA-EE-A3AD	SKCM	TCGA	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.8632
p.R1606M	DO37707	SKCM	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.8632
p.G2211V	TCGA-ER-A19P	SKCM	TCGA	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.1389
p.G2211V	DO47623	SKCM	ICGC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.1389
p.I1605T	DO227976	COCA	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.5966
p.A1618S	DO229026	LICA	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation rewiring degron network	0.1944
p.A1610S	DO229031	LICA	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation altering degron motif	0.6477
p.M2225I	DO52365	LUSC	ICGC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01169	Ovarian Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01237	Hepatocellular Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00602	Gastric Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01002	Breast Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00007	Other Solid Cancers	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01716	Non-Cancerous	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00175	Melanoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00214	Colorectal Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM00280	Gastric Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01721	Non-Cancerous	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.M2225I	SIDM01619	Endometrial Carcinoma	GDSC	AGTST	DEG_SPOP_SBC_1	2218:2222	Mutation rewiring degron network	0.25
p.A1598T	DO38404	STAD	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	1605:1613	Mutation rewiring degron network	0.1389

Kaplan plot for DNAJC13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJC13

UniProt ID: O75165

Entrez ID: 23317

Protein name: DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJC13 in