DegronMD

Uniprot ID: O75165

Source protein: DnaJ homolog subfamily C member 13

Source gene: DNAJC13

Class: DEG_APCC_DBOX_1

Location: 1605:1613

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.894

ASA_SCORE: 44.0556

COIL: 0.2466

CONS_SCORE: 0.5033

DSS_SCORE: 0.3027

HELIX: 0.7456

FCONS_SCORE: 1.1735

RIG_SCORE: 0.7875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1605V	TCGA-56-8628	LUSC	TCGA	IRKSLAGML	DEG_APCC_DBOX_1	0.5965
p.I1605V	DO45433	LUSC	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.5965
p.I1605V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IRKSLAGML	DEG_APCC_DBOX_1	0.5965
p.G1611V	TCGA-A6-3809	COAD	TCGA	IRKSLAGML	DEG_APCC_DBOX_1	0.6421
p.G1611V	DO8722	COAD	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.6421
p.R1606M	TCGA-EE-A3AD	SKCM	TCGA	IRKSLAGML	DEG_APCC_DBOX_1	0.8632
p.R1606M	DO37707	SKCM	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.8632
p.I1605T	DO227976	COCA	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.5966
p.A1618S	DO229026	LICA	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.1944
p.A1610S	DO229031	LICA	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.6477
p.A1598T	DO38404	STAD	ICGC	IRKSLAGML	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75165	DnaJ homolog subfamily C member 13	DEG_APCC_DBOX_1	1605:1613	IRKSLAGML	APC,CDC20,FZR1	0.894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons