DegronMD

Uniprot ID: Q03164

Source protein: Histone-lysine N-methyltransferase 2A

Source gene: KMT2A

Class: DEG_SCF_FBW7_1

Location: 2145:2151

E3 ligase: FBXW7

DEGRON score: 0.9867

ASA_SCORE: 90.3

COIL: 0.9339

CONS_SCORE: 0.3504

DSS_SCORE: 0.6168

HELIX: 0.0127

FCONS_SCORE: 0.9953

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2151L	TCGA-FA-A82F	DLBC	TCGA	IRTPSYS	DEG_SCF_FBW7_1	0.7582
p.P2151S	TCGA-FW-A3R5	SKCM	TCGA	IRTPSYS	DEG_SCF_FBW7_1	0.6752
p.R2160Q	DO36556	READ	ICGC	IRTPSYS	DEG_SCF_FBW7_1	0.0833
p.R2160Q	DO41331	UCEC	ICGC	IRTPSYS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SCF_FBW7_1	2145:2151	IRTPSYS	FBXW7	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons